A stochastic model for the origin and treatment of tumors containing drug-resistant cells (Q1820076)
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scientific article; zbMATH DE number 3993349
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| English | A stochastic model for the origin and treatment of tumors containing drug-resistant cells |
scientific article; zbMATH DE number 3993349 |
Statements
A stochastic model for the origin and treatment of tumors containing drug-resistant cells (English)
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1986
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A stochastic model for the chemotherapy of experimental tumors is presented. The focus of this model is on the presence of drug-resistant mutants and their influence on eventual treatment outcome. Equations are derived for the joint probability-generating function for the number of chemo-sensitive and chemo-resistant cells. The model is extended to two drugs and it is shown how the model may be used to make deductions regarding the optimum scheduling of therapy.
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Kolmogorov forward equations
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stochastic model
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chemotherapy of experimental tumors
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drug-resistant mutants
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joint probability-generating function
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chemo-sensitive and chemo-resistant cells
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optimum scheduling of therapy
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0.8633344769477844
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0.8537412285804749
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0.8340680003166199
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0.8233987092971802
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0.81072998046875
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