Drug-Induced TdP Risk Assessment (Q4834866): Difference between revisions
From MaRDI portal
Changed [en] label: Drug-Induced TdP Risk Assessment |
Changed claim: description (P1459): A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset provides 4 torsade de pointes (TdP) risk categories. For all 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained (Llopis-Lorente et al., 2020). |
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| Property / description | Property / description | ||
A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset provides 4 torsade de pointes (TdP) risk categories. For all 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained (Llopis-Lorente et al., 2020). | |||
Revision as of 09:03, 10 April 2025
Dataset in the Graphical Modelling and Causal Inference Zenodo Community
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Drug-Induced TdP Risk Assessment |
Dataset in the Graphical Modelling and Causal Inference Zenodo Community |
Statements
20 June 2023
0 references
A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset provides 4 torsade de pointes (TdP) risk categories. For all 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained (Llopis-Lorente et al., 2020).
0 references
