Computational methods for comparing two binary diagnostic tests in the presence of partial verification of disease (Q638052): Difference between revisions
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Revision as of 19:32, 19 March 2024
scientific article
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English | Computational methods for comparing two binary diagnostic tests in the presence of partial verification of disease |
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Computational methods for comparing two binary diagnostic tests in the presence of partial verification of disease (English)
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8 September 2011
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The authors consider data of application of two binary diagnostic tests of some disease to a set (sample) of patients. The true status of the patients is known for only a subsample. The problem is to estimate the sensitivity and specificity of the tests. The Vacek model of conditional dependence is assumed for the tests results where the dependence is modeled as a multiplicative factor. A EM-type algorithm is proposed for the calculation of the maximum likelihood estimates and a SEM algorithm is described for the estimation of the covariances. Results of simulations and application to the diagnostic of coronary stenosis are presented.
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specificity
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sensitivity
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SEM-algorithm
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maximum likelihood estimates
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