EmpiricalCalibration (Q28244): Difference between revisions

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point in time: 1 January 2024
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Latest revision as of 17:32, 21 March 2024

Routines for Performing Empirical Calibration of Observational Study Estimates
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EmpiricalCalibration
Routines for Performing Empirical Calibration of Observational Study Estimates

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    3.1.1
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    1.1.0
    15 February 2016
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    2.0.1
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    3.0.0
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    3.1.2
    21 December 2023
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    21 December 2023
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    Routines for performing empirical calibration of observational study estimates. By using a set of negative control hypotheses we can estimate the empirical null distribution of a particular observational study setup. This empirical null distribution can be used to compute a calibrated p-value, which reflects the probability of observing an estimated effect size when the null hypothesis is true taking both random and systematic error into account. A similar approach can be used to calibrate confidence intervals, using both negative and positive controls. For more details, see Schuemie et al. (2013) <doi:10.1002/sim.5925> and Schuemie et al. (2018) <doi:10.1073/pnas.1708282114>.
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