The dynamics of gene amplification described as a multitype compartmental model and as a branching process (Q2277181)

From MaRDI portal
Revision as of 15:12, 21 June 2024 by ReferenceBot (talk | contribs) (‎Changed an Item)
scientific article
In more languages
Configure
Language Label Description Also known as
English
The dynamics of gene amplification described as a multitype compartmental model and as a branching process
scientific article

    Statements

    The dynamics of gene amplification described as a multitype compartmental model and as a branching process (English)
    Gene amplification (GA) is by now a well-documented phenomenon in many natural areas and it can be regarded as one of the mechanisms that yield to drug resistance in the treatment of cancer. In this paper various mathematical models are developed to describe the dynamics of gene amplification. At first, using difference equations, some expressions are given for the expectations of certain random variables such as the number of cells having k copies of a specified gene or the size of drug sensitive cells with the loss of cells taken either as constant or as copy-number dependent. It is found that for one-copy GA processes the relative frequency of sensitive cells converges to zero in the case of a constant loss probability and otherwise it has a lower bound. In the second part the GA for single-gene-copy cells is described by a branching process which leads to formulas for the probability generating function (PGF) and the expectation, which are similar to those presented in the first part, and for the variance. A simple consequence then leads to conditions for a.s. extinction. Afterwards for a simple three-type model the PGF and the expectation matrix are given. Finally, the gene amplification is described as a general multitype branching process where the expectation matrix is given for different GA situations such as stable or unstable one-copy and multi-copy GA.
    Galton-Watson process
    drug resistance
    treatment of cancer
    dynamics of gene amplification
    difference equations
    drug sensitive cells
    probability generating function
    a.s. extinction
    expectation matrix
    multitype branching process

    Identifiers