Pharmacological dataset on drug-induced TdP risk assessment (Q4834866)
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Dataset in the Graphical Modelling and Causal Inference Zenodo Community
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Pharmacological dataset on drug-induced TdP risk assessment |
Dataset in the Graphical Modelling and Causal Inference Zenodo Community |
Statements
20 June 2023
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A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset provides 4 torsade de pointes (TdP) risk categories. For all 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained (Llopis-Lorente et al., 2020).
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