Optimal designs for contingent response models with application to toxicity-efficacy studies

DOI10.1016/J.JSPI.2013.03.025zbMath1278.62117OpenAlexW2069728914MaRDI QIDQ389259

Huwaida Rabie, Nancy Flournoy

Publication date: 20 January 2014

Published in: Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jspi.2013.03.025

zbMATH Keywords

experimental designsbivariate responsescontinuation ratio modeldose-findingnonlinear response functionsphase II clinical trials

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Optimal statistical designs (62K05)

Related Items (4)

Optimal cutpoints for random observations ⋮ Optimal designs for contingent response models with application to toxicity-efficacy studies ⋮ A response-driven adaptive design based on the Klein urn ⋮ On optimal designs for clinical trials: an updated review

Cites Work

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• Optimal designs for contingent response models with application to toxicity-efficacy studies
• The treatment versus experimentation dilemma in dose finding studies
• Approximate dynamic programming and its applications to the design of Phase I cancer trials
• On the de la Garza phenomenon
• Penalized optimal designs for dose-finding
• General equivalence theory for optimum designs (approximate theory)
• Model-oriented design of experiments
• Optimal designs and limiting optimal designs for a trinomial response
• D-optimal designs for logistic models with three and four parameters
• Adaptive designs for selecting drug combinations based on efficacy-toxicity response
• Adaptive designs for dose-finding based on efficacy-toxicity response
• Compound optimal allocation for individual and collective ethics in binary clinical trials
• Some Properties for a Simplified Cox Binary Model
• Model Robust, Linear-Optimal Designs
• A sequential design for maximizing the probability of a favourable response
• The Sequential Generation of $D$-Optimum Experimental Designs

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