Optimal designs for contingent response models with application to toxicity-efficacy studies

DOI10.1016/J.JSPI.2013.03.025zbMATH Open1278.62117OpenAlexW2069728914MaRDI QIDQ389259FDOQ389259

Authors: Huwaida Rabie, Nancy Flournoy 

Publication date: 20 January 2014

Published in: Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jspi.2013.03.025

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zbMATH Keywords

dose-findingbivariate responsescontinuation ratio modelexperimental designsnonlinear response functionsphase II clinical trials

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Optimal statistical designs (62K05)

Cites Work

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• General equivalence theory for optimum designs (approximate theory)
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• D-optimal designs for logistic models with three and four parameters
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• Penalized optimal designs for dose-finding
• Optimal designs and limiting optimal designs for a trinomial response
• Compound optimal allocation for individual and collective ethics in binary clinical trials
• Some Properties for a Simplified Cox Binary Model
• Optimal designs for contingent response models with application to toxicity-efficacy studies
• A sequential design for maximizing the probability of a favourable response
• Approximate dynamic programming and its applications to the design of Phase I cancer trials

Cited In (12)

• Optimal designs for discriminating between dose-response models in toxicology studies
• On optimal designs for clinical trials: an updated review
• Optimal adaptive designs for acute oral toxicity assessment
• Optimal designs and limiting optimal designs for a trinomial response
• Optimal designs for response functions with a downturn
• A response-driven adaptive design based on the Klein urn
• Optimal experimental designs for estimating the drug combination index in toxicology
• Optimal designs for dose-finding experiments in toxicity studies
• Optimal cutpoints for random observations
• Optimal design to discriminate between rival copula models for a bivariate binary response
• Optimal designs for contingent response models with application to toxicity-efficacy studies
• Optimal designs for estimating critical effective dose under model uncertainty in a dose response study

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