Optimal designs for response functions with a downturn

DOI10.1016/J.JSPI.2010.07.003MaRDI QIDQ710822zbMATH OpenOpenAlexFDO

Authors Seung Won Hyun, Min Yang, Nancy Flournoy

Publication date 22 October 2010

Published in Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jspi.2010.07.003

zbMATH Keywords

experimental designD-optimalityA-optimalitydose-response\(EC_{50}\)D\(_A\)-optimalityendocrine-disrupting chemicalslaboratory studiesnonlinear response functionoptimal weightspeak dosesuccessive mean differencestoxicological assays

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Optimal statistical designs (62K05)

Recommendations

• On the combination of \(c\)- and \(D\)-optimal designs: general approaches and applications in dose-response studies
• Optimal designs for estimating critical effective dose under model uncertainty in a dose response study
• Optimal designs for discriminating between dose-response models in toxicology studies
• Optimal designs for contingent response models with application to toxicity-efficacy studies
• Optimal designs for dose-finding experiments in toxicity studies

Cites work

• scientific article; zbMATH DE number 54240 (Why is no real title available?)
• scientific article; zbMATH DE number 1077338 (Why is no real title available?)
• A note on optimal designs for two or more treatment groups
• Adaptive designs for selecting drug combinations based on efficacy-toxicity response
• Support points of locally optimal designs for nonlinear models with two parameters

Cited in

(2)

• Optimal designs based on the maximum quasi-likelihood estimator
• A procedure for finding an improved upper bound on the number of optimal design points

This page was built for publication: Optimal designs for response functions with a downturn

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q710822)