Optimal adaptive designs for acute oral toxicity assessment

DOI10.1016/J.JSPI.2005.08.004MaRDI QIDQ2492920zbMATH OpenOpenAlexWikidataFDO

Authors Nigel Stallard

Publication date 9 June 2006

Published in Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jspi.2005.08.004

zbMATH Keywords

backward inductionBayesian decision theoryBayesian optimal designLD\(_{50}\) estimationutility functions

Mathematics Subject Classification ID

Bayesian problems; characterization of Bayes procedures (62C10) Optimal statistical designs (62K05) Applications of statistics to biology and medical sciences; meta analysis (62P10) Dynamic programming (90C39)

Recommendations

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• Optimal designs for active controlled dose-finding trials with efficacy-toxicity outcomes
• Optimal designs for contingent response models with application to toxicity-efficacy studies
• Optimum experimental designs for comparative bioavailability studies

Cites work

• A Method for Obtaining and Analyzing Sensitivity Data
• A sequential design for maximizing the probability of a favourable response
• A Stochastic Approximation Method
• scientific article; zbMATH DE number 3126094 (Why is no real title available?)
• scientific article; zbMATH DE number 3255204 (Why is no real title available?)
• scientific article; zbMATH DE number 3361160 (Why is no real title available?)
• Outliers in Circular Data
• Statistical decision theory and Bayesian analysis. 2nd ed
• The Up-and-Down Method with Small Samples
• Using Path Induction to Evaluate Sequential Allocation Procedures

Cited in

(2)

• Integrated testing strategies can be optimal for chemical risk classification
• Cumulative cohort design for dose-finding

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