Optimum experimental designs for comparative bioavailability studies

DOI10.1016/0378-3758(94)90201-1MaRDI QIDQ1338369zbMATH OpenOpenAlexFDO

Authors Hegang Chen, A. S. Hedayat

Publication date 18 December 1994

Published in Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0378-3758(94)90201-1

zbMATH Keywords

absorption/distribution/metabolism/elimination profileBIB designcomparative bioavailability studiesfinite geometriesm-component drug-drug interaction bioavailability studiespharmacokinetic drug-drug interaction studyresistant block designsstrongly universal optimalityvariance balanced design

Mathematics Subject Classification ID

Optimal statistical designs (62K05) Statistical block designs (62K10) Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Cites work

• scientific article; zbMATH DE number 3943824 (Why is no real title available?)
• scientific article; zbMATH DE number 3490283 (Why is no real title available?)
• scientific article; zbMATH DE number 3352656 (Why is no real title available?)
• scientific article; zbMATH DE number 3052150 (Why is no real title available?)
• Pairwise-balanced, variance-balanced and resistant incomplete block designs revisited
• Resistant and susceptible BIB designs

Cited in

(5)

• Optimal experimental designs for estimating the drug combination index in toxicology
• Optimal adaptive designs for acute oral toxicity assessment
• Optimal 3×3 factorial and 3-ray designs for drug interaction experiments with dichotomous responses
• Experimental designs for the estimation of the concentration curve and the AUC
• A bound for efficiency in multiple response designs

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