Detection boundary and higher criticism approach for rare and weak genetic effects

DOI10.1214/14-AOAS724zbMath1454.62420arXiv1407.8382OpenAlexW1994005523MaRDI QIDQ400613

Zheyang Wu, Yiming Sun, Judy Cho, Shiquan He, Jiashun Jin, Hongyu Zhao

Publication date: 22 August 2014

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1407.8382

zbMATH Keywords

higher criticismlarge-scale inferencerare and weak effectsgenome-wide association studiesdetection boundarystatistical powermultiple hypotheses testingSNP-set methods

Mathematics Subject Classification ID

Nonparametric hypothesis testing (62G10) Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10)

Related Items (10)

An adaptive decorrelation procedure for signal detection ⋮ Powerful test based on conditional effects for genome-wide screening ⋮ Group feature screening via the F statistic ⋮ TFisher: a powerful truncation and weighting procedure for combining \(p\)-values ⋮ Detection boundary and higher criticism approach for rare and weak genetic effects ⋮ Anomaly Detection for a Large Number of Streams: A Permutation-Based Higher Criticism Approach ⋮ Signal-noise ratio of genetic associations and statistical power of SNP-set tests ⋮ Global testing against sparse alternatives under Ising models ⋮ Accurate and Efficient P-value Calculation Via Gaussian Approximation: A Novel Monte-Carlo Method ⋮ Higher criticism for large-scale inference, especially for rare and weak effects

Uses Software

• mvtBinaryEP
• pi-MASS
• UniProt
• QuickGO

Cites Work

• Unnamed Item
• Innovated higher criticism for detecting sparse signals in correlated noise
• Bayesian variable selection regression for genome-wide association studies and other large-scale problems
• Feature selection when there are many influential features
• Detection boundary and higher criticism approach for rare and weak genetic effects
• Global testing under sparse alternatives: ANOVA, multiple comparisons and the higher criticism
• Adaptive detection of a signal of growing dimension. II
• Higher criticism for detecting sparse heterogeneous mixtures.
• Detection boundary in sparse regression
• Size, power and false discovery rates
• Properties of higher criticism under strong dependence
• On model selection strategies to identify genes underlying binary traits using genomewide association data via spline smoothing
• Higher criticism thresholding: Optimal feature selection when useful features are rare and weak
• Sample size and power analysis for sparse signal recovery in genome-wide association studies
• Limit theorems for the ratio of the empirical distribution function to the true distribution function
• Empirical Bayes Analysis of a Microarray Experiment
• Correlation and Large-Scale Simultaneous Significance Testing
• Semiparametric Regression of Multidimensional Genetic Pathway Data: Least‐Squares Kernel Machines and Linear Mixed Models
• Large-Scale Simultaneous Hypothesis Testing
• Hypothesis testing in semiparametric additive mixed models

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