Optimal control of tumor size used to maximize survival time when cells are resistant to chemotherapy

DOI10.1016/0025-5564(92)90038-XzbMath0754.92012OpenAlexW2039766809WikidataQ44456843 ScholiaQ44456843MaRDI QIDQ1196632

R. F. Minchin, Michael E. Fisher, Kok Lay Teo, R. Bruce Martin

Publication date: 16 January 1993

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0025-5564(92)90038-x

zbMATH Keywords

chemotherapydrug resistanceexponential tumor growthtumor growth modelfeedback controlssurvival timeanticancer drugsGompertz tumor growthlogistic tumor growthoptimal tumor mass

Mathematics Subject Classification ID

Application models in control theory (93C95) Medical applications (general) (92C50)

Related Items (10)

The contribution of evolutionary game theory to understanding and treating cancer ⋮ A mathematical model of periodically pulsed chemotherapy: Tumor recurrence and metastasis in a competitive environment ⋮ Optimizing combination therapy in a murine model of HER2+ breast cancer ⋮ Tumor containment: a more general mathematical analysis ⋮ Evolutionary games and applications: fifty years of `the logic of animal conflict' ⋮ A survey of optimization models on cancer chemotherapy treatment planning ⋮ Stochastic optimal control in a danger zone ⋮ Maximization of viability time in a mathematical model of cancer therapy ⋮ Optimisation of Cancer Drug Treatments Using Cell Population Dynamics ⋮ Analyzing the quality robustness of chemotherapy plans with respect to model uncertainties

Cites Work

• Unnamed Item
• A model for the resistance of tumor cells to cancer chemotherapeutic agents
• The effect of cellular differentiation on the development of permanent drug resistance
• The transient solution of the linear birth-death process with random spontaneous mutation
• A stochastic model for the origin and treatment of tumors containing drug-resistant cells
• Functional analysis and time optimal control
• On Certain Questions in the Theory of Optimal Control

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