The influence of fixed and free final time of treatment on optimal chemotherapeutic protocols

DOI10.1016/S0895-7177(98)00029-6zbMath0896.92015MaRDI QIDQ1388959

M. I. S. Costa, José Luiz Boldrini

Publication date: 6 October 1998

Published in: Mathematical and Computer Modelling (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/s0895-7177(98)00029-6

zbMATH Keywords

free final time; chemotherapeutic treatments; exponential cell growth; optimal drug regimen

Mathematics Subject Classification ID

49N70: Differential games and control

92C50: Medical applications (general)

49N75: Pursuit and evasion games

49K15: Optimality conditions for problems involving ordinary differential equations

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Cites Work

• Role of optimal control theory in cancer chemotherapy
• Optimal control analysis in the chemotherapy of IgG multiple myeloma
• Singularity of optimal control in some problems related to optimal chemotherapy
• Drug kinetics and drug resistance in optimal chemotherapy
• Chemotherapeutic treatments involving drug resistance and level of normal cells as a criterion of toxicity
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