Optimal therapy scheduling based on a pair of collaterally sensitive drugs

DOI10.1101/196824zbMath1396.92040OpenAlexW2764019985WikidataQ53686338 ScholiaQ53686338MaRDI QIDQ1670458

Nara Yoon, Robert Vander Velde, Andriy Marusyk, Jacob G. Scott

Publication date: 5 September 2018

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1101/196824

zbMATH Keywords

optimal controldynamical systemscancerevolution of resistance

Mathematics Subject Classification ID

Applications of optimal control and differential games (49N90) Medical applications (general) (92C50)

Related Items (5)

Modelling bistable tumour population dynamics to design effective treatment strategies ⋮ Scheduling collateral sensitivity‐based cycling therapies toward eradication of drug‐resistant infections ⋮ Inferring density-dependent population dynamics mechanisms through rate disambiguation for logistic birth-death processes ⋮ Theoretical modeling of collaterally sensitive drug cycles: shaping heterogeneity to allow adaptive therapy ⋮ The impact of competition between cancer cells and healthy cells on optimal drug delivery

Cites Work

• The mathematical modelling of adjuvant chemotherapy scheduling: incorporating the effects of protocol rest phases and pharmacokinetics
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• A mathematical model to study the effects of drug resistance and vasculature on the response of solid tumors to chemotherapy
• The application of mathematical modelling to aspects of adjuvant chemotherapy scheduling
• An elementary approach to modeling drug resistance in cancer
• Optimal policies of non-cross-resistant chemotherapy on Goldie and Coldman's cancer model
• The influence of toxicity constraints in models of chemotherapeutic protocol escalation

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