A stochastic carcinogenesis model incorporating multiple types of genomic instability fitted to colon cancer data

DOI10.1016/J.JTBI.2008.05.027zbMath1400.92269OpenAlexW1965853112WikidataQ31163759 ScholiaQ31163759MaRDI QIDQ1797469

Guangquan Li, Mark P. Little, Paolo Vineis

Publication date: 22 October 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2008.05.027

zbMATH Keywords

chromosomal instabilitycarcinogenesismicrosatellite instabilitycolon cancergenomic instabilitystochastic quasi-mechanistic models

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Medical applications (general) (92C50)

Related Items (6)

Evolution of genetic instability in heterogeneous tumors ⋮ A rapid-mutation approximation for cell population dynamics ⋮ New stochastic carcinogenesis model with covariates: an approach involving intracellular barrier mechanisms ⋮ The impact of radiation on the development of lung cancer ⋮ Simulating the dynamics of atherosclerosis to the incidence of myocardial infarction, applied to the KORA population ⋮ Risk of lung cancer due to external environmental factor and epidemiological data analysis

Uses Software

• nag
• bootlib
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Cites Work

• Two-event models for carcinogenesis: Incidence curves for childhood and adult tumors
• A stochastic carcinogenesis model incorporating genomic instability fitted to colon cancer data
• Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability
• Are Two Mutations Sufficient to Cause Cancer? Some Generalizations of the Two-Mutation Model of Carcinogenesis of Moolgavkar, Venzon, and Knudson, and of the Multistage Model of Armitage and Doll
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