Evolution of genetic instability in heterogeneous tumors

DOI10.1016/J.JTBI.2015.11.028MaRDI QIDQ306758zbMATHOpenAlexWikidataFDO

Authors Ani D. Asatryan, Natalia L. Komarova

Publication date 1 September 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL http://europepmc.org/articles/pmc5680090

zbMATH Keywords

chromosomal instabilitydriver mutationmicrosatellite instabilitypassenger mutation

Mathematics Subject Classification ID

Medical applications (general) (92C50) Genetics and epigenetics (92D10)

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• A stochastic carcinogenesis model incorporating multiple types of genomic instability fitted to colon cancer data
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Cited in

(14)

• Genetic instability and clonal expansion
• A stochastic individual-based model to explore the role of spatial interactions and antigen recognition in the immune response against solid tumours
• Effects of mutations and immunogenicity on outcomes of anti-cancer therapies for secondary lesions
• Measuring evolutionary cancer dynamics from genome sequencing, one patient at a time
• Genetic instability and the quasispecies model
• The evolution of tumor metastases during clonal expansion
• A mathematical model to study the impact of intra-tumour heterogeneity on anti-tumour CD\(8^+\) T cell immune response
• The role of telomere shortening in carcinogenesis: a hybrid stochastic-deterministic approach
• Stochastic multi-scale models of competition within heterogeneous cellular populations: simulation methods and mean-field analysis
• Cancer stem cells as the engine of unstable tumor progression
• Evolutionary dynamics of phenotype-structured populations: from individual-level mechanisms to population-level consequences
• Risk of lung cancer due to external environmental factor and epidemiological data analysis
• On the probability of random genetic mutations for various types of tumor growth
• Fastest time to cancer by loss of tumor suppressor genes

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