Measuring evolutionary cancer dynamics from genome sequencing, one patient at a time

DOI10.1515/sagmb-2020-0075zbMath1461.92071OpenAlexW3117492868MaRDI QIDQ830656

Giulio Caravagna

Publication date: 7 May 2021

Published in: Statistical Applications in Genetics and Molecular Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1515/sagmb-2020-0075

zbMATH Keywords

clonal evolutionbulk genome sequencingsubclonal deconvolution

Mathematics Subject Classification ID

Problems related to evolution (92D15) Protein sequences, DNA sequences (92D20) Genetics and epigenetics (92D10) Pathology, pathophysiology (92C32)

Uses Software

• GitHub
• PhyloWGS
• PyClone
• SciClone
• TEMULATOR
• PRMLT

Cites Work

• Line-of-descent and genealogical processes, and their applications in population genetics models
• Scaling solution in the large population limit of the general asymmetric stochastic Luria-Delbrück evolution process
• Conjunctive Bayesian networks
• Exact solution of a two-type branching process: clone size distribution in cell division kinetics
• Large population solution of the stochastic Luria–Delbrück evolution model
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