A unifying concept for the amino acid code

DOI10.1007/BF02460068MaRDI QIDQ792258zbMATH OpenWikidataFDO

Authors Rosemarie Swanson

Publication date 1984

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/BF02460068

zbMATH Keywords

amino acid codeGray codestructure of the genetic codeunifying concept

Mathematics Subject Classification ID

Physiological, cellular and medical topics (92Cxx) Genetics and epigenetics (92D10)

Review text

The structure of the genetic code is related to a Gray code, which is a plausible theoretical model for an amino acid code. The proposed model implies that the most important factor in shaping the code was the effects of mistakes in translation, not effects of mutations. Another possible implication is that the preservation of stiffness and flexibility at appropriate places in a protein chain is as important in protein structure as the appropriate placement of hydrophilic (external) and hydrophobic (internal) residues. Other results are a simple conceptualization of the relationships among the 20 amino acids and their relations to their codons.

Recommendations

• Stability of the genetic code and optimal parameters of amino acids
• The genetic code is not an optimal code in a model taking into account both the biosynthetic relationships between amino acids and their physicochemical properties
• Measure of similarity of amino acids or how to obtain the genetic code table from ``nothing
• On amino acid and codon assignment in algebraic models for the genetic code
• scientific article; zbMATH DE number 4008167

Cites work

• Multidimensional scaling, tree-fitting, and clustering
• The analysis of proximities: Multidimensional scaling with an unknown distance function: I, II

Cited in

(12)

• Pattern analysis of the genetic code
• Two classes of the aminoacyl-tRNA synthetases in correspondence with the codon path cube
• 2-adic clustering of the PAM matrix
• The rules of variation: amino acid exchange according to the rotating circular genetic code
• Ultrametrics in the genetic code and the genome
• A harmonic structure of the genetic code
• Protein evolution within and between species
• Methods and applications of ultrametric and \(p\)-adic analysis: from wavelet theory to biophysics
• Micro-RNAs: viral genome and robustness of gene expression in the host
• Modeling the genetic code: \(p\)-adic approach
• 2-adic numbers in genetics and Rumer's symmetry
• Studying genetic code by a matrix approach

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