Adaptive evolution on neutral networks

DOI10.1006/BULM.2001.0244MaRDI QIDQ886887zbMATH OpenOpenAlexWikidataFDO

Authors Claus O. Wilke

Publication date 27 October 2015

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/physics/0101021

zbMATH Keywords

adaptationneutral mutationsasexual populationshigher fitness genotypesstrongly deleterious mutations

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Abstract: We study the evolution of large but finite asexual populations evolving in fitness landscapes in which all mutations are either neutral or strongly deleterious. We demonstrate that despite the absence of higher fitness genotypes, adaptation takes place as regions with more advantageous distributions of neutral genotypes are discovered. Since these discoveries are typically rare events, the population dynamics can be subdivided into separate epochs, with rapid transitions between them. Within one epoch, the average fitness in the population is approximately constant. The transitions between epochs, however, are generally accompanied by a significant increase in the average fitness. We verify our theoretical considerations with two analytically tractable bitstring models.

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• Evolution of a population of random Boolean networks
• ParadisEO-MO: from fitness landscape analysis to efficient local search algorithms
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• Adaptive walks on high-dimensional fitness landscapes and seascapes with distance-dependent statistics
• The role of weak selection and high mutation rates in nearly neutral evolution
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• Dynamical community structure of populations evolving on genotype networks
• Entropic contribution to phenotype fitness
• Metastable evolutionary dynamics: crossing fitness barriers or escaping via neutral paths?
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• Fitness landscape of the cellular automata majority problem: view from the ``Olympus
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• Neutral Fitness Landscape in the Cellular Automata Majority Problem
• Selective pressures on genomes in molecular evolution
• Speeding up evolutionary search by small fitness fluctuations
• Evolutionary coupling between the deleteriousness of gene mutations and the amount of non-coding sequences
• Neutrality in fitness landscapes.
• The rate at which asexual populations cross fitness valleys
• MUTUAL SELECTION IN NETWORK EVOLUTION: THE ROLE OF THE INTRINSIC FITNESS
• scientific article; zbMATH DE number 2087177 (Why is no real title available?)

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