Adaptive evolution on neutral networks

DOI10.1006/BULM.2001.0244MaRDI QIDQ886887zbMATH OpenOpenAlexWikidataFDO

Authors Claus O. Wilke

Publication date 27 October 2015

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/physics/0101021

zbMATH Keywords

adaptationasexual populationshigher fitness genotypesneutral mutationsstrongly deleterious mutations

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Abstract: We study the evolution of large but finite asexual populations evolving in fitness landscapes in which all mutations are either neutral or strongly deleterious. We demonstrate that despite the absence of higher fitness genotypes, adaptation takes place as regions with more advantageous distributions of neutral genotypes are discovered. Since these discoveries are typically rare events, the population dynamics can be subdivided into separate epochs, with rapid transitions between them. Within one epoch, the average fitness in the population is approximately constant. The transitions between epochs, however, are generally accompanied by a significant increase in the average fitness. We verify our theoretical considerations with two analytically tractable bitstring models.

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Cited in

(23)

• Evolution on a smooth landscape: The role of bias
• The role of weak selection and high mutation rates in nearly neutral evolution
• The pace of evolution across fitness valleys
• A trade-off between neutrality and adaptability limits the optimization of viral quasispecies
• Simple quasispecies models for the survival-of-the-flattest effect: the role of space
• Selective pressures on genomes in molecular evolution
• Selection for mutational robustness in finite populations
• Evolutionary coupling between the deleteriousness of gene mutations and the amount of non-coding sequences
• Adaptive walks on high-dimensional fitness landscapes and seascapes with distance-dependent statistics
• ParadisEO-MO: from fitness landscape analysis to efficient local search algorithms
• Neutral Fitness Landscape in the Cellular Automata Majority Problem
• MUTUAL SELECTION IN NETWORK EVOLUTION: THE ROLE OF THE INTRINSIC FITNESS
• scientific article; zbMATH DE number 2087177 (Why is no real title available?)
• scientific article; zbMATH DE number 1901180 (Why is no real title available?)
• Neutrality in fitness landscapes.
• Optimal adaptive performance and delocalization in NK fitness landscapes
• Entropic contribution to phenotype fitness
• The rate at which asexual populations cross fitness valleys
• Speeding up evolutionary search by small fitness fluctuations
• Dynamical community structure of populations evolving on genotype networks
• Fitness landscape of the cellular automata majority problem: view from the ``Olympus
• Metastable evolutionary dynamics: crossing fitness barriers or escaping via neutral paths?
• Evolution of a population of random Boolean networks

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