The pace of evolution across fitness valleys

DOI10.1016/J.JTBI.2009.04.011MaRDI QIDQ1624459zbMATH OpenOpenAlexWikidataFDO

Authors Chaitanya S. Gokhale, Yoh Iwasa, Martin A. Nowak, Arne Traulsen

Publication date 16 November 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1003.5828, http://europepmc.org/articles/pmc2711507

zbMATH Keywords

evolutionary speedfinite populationsstochastic tunneling

Mathematics Subject Classification ID

Problems related to evolution (92D15)

Abstract: How fast does a population evolve from one fitness peak to another? We study the dynamics of evolving, asexually reproducing populations in which a certain number of mutations jointly confer a fitness advantage. We consider the time until a population has evolved from one fitness peak to another one with a higher fitness. The order of mutations can either be fixed or random. If the order of mutations is fixed, then the population follows a metaphorical ridge, a single path. If the order of mutations is arbitrary, then there are many ways to evolve to the higher fitness state. We address the time required for fixation in such scenarios and study how it is affected by the order of mutations, the population size, the fitness values and the mutation rate.

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Cited in

(12)

• Evolution in action across phylogeny caused by microclimatic stresses at ``Evolution canyon (Mini review of a research project)
• Evolutionary accessibility in tunably rugged fitness landscapes
• Evolutionary accessibility of modular fitness landscapes
• The fastest evolutionary trajectory
• Crossing a fitness valley as a metastable transition in a stochastic population model
• The expected time to cross extended fitness plateaus
• Characteristic time in quasispecies evolution
• Landscape structure and the speed of adaptation
• The rate at which asexual populations cross fitness valleys
• A general multi-scale description of metastable adaptive motion across fitness valleys
• Fitness-valley crossing with generalized parent-offspring transmission
• Metastable evolutionary dynamics: crossing fitness barriers or escaping via neutral paths?

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