Crossing a fitness valley as a metastable transition in a stochastic population model

DOI10.1214/19-AAP1487zbMATH Open1433.92033arXiv1801.06473MaRDI QIDQ2299586FDOQ2299586

Authors: Anton Bovier, Loren Coquille, Charline Smadi 

Publication date: 21 February 2020

Published in: The Annals of Applied Probability (Search for Journal in Brave)

Abstract: We consider a stochastic model of population dynamics where each individual is characterised by a trait in {0,1,...,L} and has a natural reproduction rate, a logistic death rate due to age or competition and a probability of mutation towards neighbouring traits at each reproduction event. We choose parameters such that the induced fitness landscape exhibits a valley: mutant individuals with negative fitness have to be created in order for the population to reach a trait with positive fitness. We focus on the limit of large population and rare mutations at several speeds. In particular, when the mutation rate is low enough, metastability occurs: the exit time of the valley is random, exponentially distributed.

Full work available at URL: https://arxiv.org/abs/1801.06473

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zbMATH Keywords

couplingeco-evolutionselective sweepbirth and death process with immigrationcompetitive Lotka-Volterra system with mutations

Mathematics Subject Classification ID

Problems related to evolution (92D15) Applications of branching processes (60J85) Population dynamics (general) (92D25) Ecology (92D40)

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Cited In (16)

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• Crossing time through the fitness barrier in an asymmetric multiplicative or additive landscape in the mutation-selection model
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• On \(\Lambda\)-Fleming-Viot processes with general frequency-dependent selection
• Stochastic individual-based models with power law mutation rate on a general finite trait space
• Stochastic analysis of emergence of evolutionary cyclic behavior in population dynamics with transfer
• The calculation of mean first arrival time for double mutants, crossing the fitness valley
• Fitness-valley crossing with generalized parent-offspring transmission
• A general multi-scale description of metastable adaptive motion across fitness valleys
• Metastable evolutionary dynamics: crossing fitness barriers or escaping via neutral paths?
• Sharp approximation and hitting times for stochastic invasion processes
• The pace of evolution across fitness valleys
• Multiscale eco-evolutionary models: from individuals to populations
• Population dynamics and statistical physics in synergy. Abstracts from the workshop held March 6--12, 2022
• The rate at which asexual populations cross fitness valleys

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