Genealogies of two linked neutral loci after a selective sweep in a large population of stochastically varying size

DOI10.1017/APR.2016.88MaRDI QIDQ5233169zbMATH OpenOpenAlexFDO

Authors Rebekka Brink-Spalink, Charline Smadi

Publication date 16 September 2019

Published in Advances in Applied Probability (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1502.03837

zbMATH Keywords

birth-and-death processcoalescentcouplingeco-evolutiongenetic hitchhikingselective sweep

Mathematics Subject Classification ID

Applications of branching processes (60J85) Problems related to evolution (92D15) Population dynamics (general) (92D25) Ecology (92D40)

Abstract: We study the impact of a hard selective sweep on the genealogy of partially linked neutral loci in the vicinity of the positively selected allele. We consider a sexual population of stochastically varying size and, focusing on two neighboring loci, derive an approximate formula for the neutral genealogy of a sample of individuals taken at the end of the sweep. Individuals are characterized by ecological parameters depending on their genetic type and governing their growth rate and interactions with other individuals (competition). As a consequence, the "fitness" of an individual depends on the population state and is not an intrinsic characteristic of individuals. We provide a deep insight into the dynamics of the mutant and wild type populations during the different stages of a selective sweep.

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Cited in

(11)

• The effect of recurrent mutations on genetic diversity in a large population of varying size
• An eco-evolutionary approach of adaptation and recombination in a large population of varying size
• Crossing a fitness valley as a metastable transition in a stochastic population model
• A simple, semi-deterministic approximation to the distribution of selective sweeps in large populations
• Approximating genealogies for partially linked neutral loci under a selective sweep
• Effect of beneficial sweeps and background selection on genetic diversity in changing environments
• Selective sweep and the size of the hitchhiking set
• Evolution of the ancestral recombination graph along the genome in case of selective sweep
• The effect of recurrent mutation on the linkage disequilibrium under a selective sweep
• The effect of fluctuating selection on the genealogy at a linked site
• Evolution of linkage disequilibrium of the founders in exponentially growing populations

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