An approximate sampling formula under genetic hitchhiking

DOI10.1214/105051606000000114MaRDI QIDQ997947zbMATH OpenOpenAlexWikidataFDO

Authors Peter Pfaffelhuber, Anton Wakolbinger, Alison Etheridge

Publication date 8 August 2007

Published in The Annals of Applied Probability (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/math/0503485

zbMATH Keywords

diffusion approximationYule processesstructured coalescentselective sweepsrandom ancestral partitionrandom background

Mathematics Subject Classification ID

Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Genetics and epigenetics (92D10) Problems related to evolution (92D15) Applications of branching processes (60J85) Branching processes (Galton-Watson, birth-and-death, etc.) (60J80) Processes in random environments (60K37)

Abstract: For a genetic locus carrying a strongly beneficial allele which has just fixed in a large population, we study the ancestry at a linked neutral locus. During this ``selective sweep the linkage between the two loci is broken up by recombination and the ancestry at the neutral locus is modeled by a structured coalescent in a random background. For large selection coefficients $alpha$ and under an appropriate scaling of the recombination rate, we derive a sampling formula with an order of accuracy of $mathcalO((logalpha{)}^{-2})$ in probability. In particular we see that, with this order of accuracy, in a sample of fixed size there are at most two nonsingleton families of individuals which are identical by descent at the neutral locus from the beginning of the sweep. This refines a formula going back to the work of Maynard Smith and Haigh, and complements recent work of Schweinsberg and Durrett on selective sweeps in the Moran model.

Recommendations

• Selective sweep and the size of the hitchhiking set
• Approximating genealogies for partially linked neutral loci under a selective sweep
• Evolution of the ancestral recombination graph along the genome in case of selective sweep
• Approximating selective sweeps
• The pattern of genetic hitchhiking under recurrent mutation

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Cited in

(29)

• The fixation probability and time for a doubly beneficial mutant
• The fixation probability of two competing beneficial mutations
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• A coalescent model for the effect of advantageous mutations on the genealogy of a population
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• Coalescence in a random background.

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