Diffusion processes (60J60) Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Branching processes (Galton-Watson, birth-and-death, etc.) (60J80) Applications of branching processes (60J85) Interacting random processes; statistical mechanics type models; percolation theory (60K35) Processes in random environments (60K37)
Abstract: We consider a single genetic locus which carries two alleles, labelled P and Q. This locus experiences selection and mutation. It is linked to a second neutral locus with recombination rate r. If r=0, this reduces to the study of a single selected locus. Assuming a Moran model for the population dynamics, we pass to a diffusion approximation and, assuming that the allele frequencies at the selected locus have reached stationarity, establish the joint generating function for the genealogy of a sample from the population and the frequency of the P allele. In essence this is the joint generating function for a coalescent and the random background in which it evolves. We use this to characterize, for the diffusion approximation, the probability of identity in state at the neutral locus of a sample of two individuals (whose type at the selected locus is known) as solutions to a system of ordinary differential equations. The only subtlety is to find the boundary conditions for this system. Finally, numerical examples are presented that illustrate the accuracy and predictions of the diffusion approximation. In particular, a comparison is made between this approach and one in which the frequencies at the selected locus are estimated by their value in the absence of fluctuations and a classical structured coalescent model is used.
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Cited in
(29)- The coalescent time in the presence of background fertility selection
- Multi-site adaptation in the presence of infrequent recombination
- The coalescence of intrahost HIV lineages under symmetric CTL attack
- Branching-coalescing particle systems
- Coalescence in a random background.
- Tree-valued Fleming-Viot dynamics with mutation and selection
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- Developments in coalescent theory from single loci to chromosomes
- Background selection and population differentiation
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- Sampling HIV intrahost genealogies based on a model of acute stage CTL response
- The common ancestor process revisited
- Tractable diffusion and coalescent processes for weakly correlated loci
- A coalescent model for the effect of advantageous mutations on the genealogy of a population
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- An approximate sampling formula under genetic hitchhiking
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