Selective sweeps for recessive alleles and for other modes of dominance

DOI10.1007/S00285-010-0382-4zbMATH Open1230.92036arXiv1005.5536OpenAlexW2592247453WikidataQ51637507 ScholiaQ51637507MaRDI QIDQ659034FDOQ659034

Authors: Juan-Miguel Gracia 

Publication date: 9 February 2012

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: A selective sweep describes the reduction of linked genetic variation due to strong positive selection. If s is the fitness advantage of a homozygote for the beneficial allele and h its dominance coefficient, it is usually assumed that h=1/2, i.e. the beneficial allele is co-dominant. We complement existing theory for selective sweeps by assuming that h is any value in [0,1]. We show that genetic diversity patters under selective sweeps with strength s and dominance 0<h<1 are similar to co-dominant sweeps with selection strength 2hs. Moreover, we focus on the case h=0 of a completely recessive beneficial allele. We find that the length of the sweep, i.e. the time from occurrence until fixation of the beneficial allele, is of the order of sqrt(N/s) generations, if N is the population size. Simulations as well as our results show that genetic diversity patterns in the recessive case h=0 greatly differ from all other cases.

Full work available at URL: https://arxiv.org/abs/1005.5536

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zbMATH Keywords

Beneficial mutationGenealogyGenetic hitchhiking

Mathematics Subject Classification ID

Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Problems related to evolution (92D15) Probabilistic models, generic numerical methods in probability and statistics (65C20)

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Cited In (5)

• Extinction and fixation times with dominance and inbreeding
• Effect of beneficial sweeps and background selection on genetic diversity in changing environments
• A simple, semi-deterministic approximation to the distribution of selective sweeps in large populations
• Enhancing the mathematical properties of new haplotype homozygosity statistics for the detection of selective sweeps
• The effect of recurrent mutation on the linkage disequilibrium under a selective sweep

Uses Software

• MSMS

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