Allelic frequencies given the sample's common ancestral type

DOI10.1016/0040-5809(88)90009-3MaRDI QIDQ1111487zbMATH OpenOpenAlexWikidataFDO

Authors B. Beder

Publication date 1988

Published in Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0040-5809(88)90009-3

zbMATH Keywords

2-allele modelhaploid genesinfinitely many alleles modelK- alleles modelKingman's coalescent modelMoran modelprobability generating functionstepwise mutation

Mathematics Subject Classification ID

Genetics and epigenetics (92D10)

Review text

The author considers a population of fixed size N of haploid genes in which K distinct allelic types are possible; it is assumed that the evolution of the population follows a Moran model. Then, looking backward in time, any random sample of n genes eventually has a single common ancestral gene. The probability generating function for the number of times that in a random sample of size n there was a mutation along an individual's genealogical line since the sample's common ancestor is calculated, and from this function the expected proportion of genes in a random sample which are of a particular allelic type, given the allelic type of the sample's common ancestor is derived. It is shown that the same result can be obtained using Kingman's coalescent model. These results are used in the cases of the 2-allele model, the infinitely many alleles model, and the K-alleles model with constant mutation. In the last part, a model with an infinite number of allelic types and stepwise mutation is considered.

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• Lines of descent and the coalescent
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Cites work

• scientific article; zbMATH DE number 3824228 (Why is no real title available?)
• Mutant substitutions at linked nucleotide sites
• POSITIVE DEFINITE SEQUENCES AND CANONICAL CORRELATION COEFFICIENTS1
• The coalescent
• Wandering distributions and the electrophoretic profile

Cited in

(13)

• Allele frequencies after a bottleneck
• The genetic divergence of two populations
• Coalescence in a random background.
• Allele frequency spectra in structured populations: novel-allele probabilities under the labelled coalescent
• A semigroup representation and asymptotic behavior of certain statistics of the Fisher-Wright-Moran coalescent
• On the genealogy of nested subsamples from a haploid population
• Likelihood ratios for the infinite alleles model
• Haplotypes: the joint distribution of alleles at linked loci
• Looking forwards and backwards in the multi-allelic neutral Cannings population model
• A multi-dimensional coalescent process applied to multi-allelic selection models and migration models
• Genealogical-tree probabilities in the infinitely-many-site model
• Lines of descent and the coalescent
• Allele frequencies in multigene families. II: Coalescent approach

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