Adaptive evolution on neutral networks

DOI10.1006/BULM.2001.0244zbMATH Open1323.92144arXivphysics/0101021OpenAlexW2033142425WikidataQ39576166 ScholiaQ39576166MaRDI QIDQ886887FDOQ886887

Authors: Claus O. Wilke 

Publication date: 27 October 2015

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: We study the evolution of large but finite asexual populations evolving in fitness landscapes in which all mutations are either neutral or strongly deleterious. We demonstrate that despite the absence of higher fitness genotypes, adaptation takes place as regions with more advantageous distributions of neutral genotypes are discovered. Since these discoveries are typically rare events, the population dynamics can be subdivided into separate epochs, with rapid transitions between them. Within one epoch, the average fitness in the population is approximately constant. The transitions between epochs, however, are generally accompanied by a significant increase in the average fitness. We verify our theoretical considerations with two analytically tractable bitstring models.

Full work available at URL: https://arxiv.org/abs/physics/0101021

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zbMATH Keywords

adaptationneutral mutationsasexual populationshigher fitness genotypesstrongly deleterious mutations

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Cited In (22)

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