Computer simulation for hormones related to primary thyropathy

DOI10.1007/BF00336982MaRDI QIDQ2265964zbMATH OpenOpenAlexWikidataFDO

Authors Toyomasa Hatakeyama, Hiroshi Yagi

Publication date 1985

Published in Biological Cybernetics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/bf00336982

zbMATH Keywords

convertion rate of bloodendocrinologyGraves' diseasehuman hypothalamus-anterior pituitary- thyroid system regulating basal metabolismhypothyroidismindicial responses of the hormonesmathematical modelMedical treatmentsthyroid glandthyropathytoxicosis

Mathematics Subject Classification ID

Probabilistic models, generic numerical methods in probability and statistics (65C20) Computing methodologies and applications (68U99) Medical applications (general) (92C50) Physiological, cellular and medical topics (92Cxx)

Review text

We propose a mathematical model of the human hypothalamus-anterior pituitary-thyroid system regulating basal metabolism, and practice computer simulation concerning primary thyropathy such as Graves' disease, hypothyroidism, \(T_ 4\)-toxicosis and \(T_ 3\)-toxicosis by use of this model. In order to throw light on properties of the system, indicial responses of the hormones, \(T_ 4\), \(T_ 3\), \(rT_ 3\), and TSH, and the function of the thyroid gland are computed. Medical treatments for Graves' disease and for hypothyroidism are simulated with a view to enhancing clinical significance. Performance of the simulation leads to an interesting result that when the convertion rate of blood \(T_ 4\) to blood \(T_ 3\) increases, explicit \(T_ 3\)-toxicosis occurs, although the function of the thyroid gland is normal.

Recommendations

• scientific article; zbMATH DE number 4193508
• scientific article; zbMATH DE number 4020897
• A patient-specific model of the negative-feedback control of the hypothalamus-pituitary-thyroid (HPT) axis in autoimmune (Hashimoto's) thyroiditis
• A new mathematical model of hypothalamo-pituitary-thyroid axis
• Dynamical model for thyroid

Cites work

• Identification of the dynamics of thyroid hormone metabolism
• Neuroendocrine control of thyroid secretion in living systems: A feedback control system model
• Optimal nonuniform sampling interval and test-input design for identification of physiological systems from very limited data

Cited in

(5)

• A model of the cost of delaying treatment of Hashimotos thyroiditis: thyroid cancer initiation and growth
• A homoclinic orbit in a patient-specific model of Hashimoto's thyroiditis
• A computational model of the human thyroid
• A statistical approach to logical inference in endocrine physiopathology
• A biologically based computational model for the hypothalamic-pituitary-thyroid (HPT) axis in \textit{Xenopus laevis} larvae

This page was built for publication: Computer simulation for hormones related to primary thyropathy

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2265964)