Computer simulation for hormones related to primary thyropathy (Q2265964)

We propose a mathematical model of the human hypothalamus-anterior pituitary-thyroid system regulating basal metabolism, and practice computer simulation concerning primary thyropathy such as Graves' disease, hypothyroidism, \(T_ 4\)-toxicosis and \(T_ 3\)-toxicosis by use of this model. In order to throw light on properties of the system, indicial responses of the hormones, \(T_ 4\), \(T_ 3\), \(rT_ 3\), and TSH, and the function of the thyroid gland are computed. Medical treatments for Graves' disease and for hypothyroidism are simulated with a view to enhancing clinical significance. Performance of the simulation leads to an interesting result that when the convertion rate of blood \(T_ 4\) to blood \(T_ 3\) increases, explicit \(T_ 3\)-toxicosis occurs, although the function of the thyroid gland is normal.