Controlled Drug Release Asymptotics

DOI10.1137/S0036139995293269MaRDI QIDQ4210035zbMATH OpenFDO

Authors T. Erneux, Donald S. Cohen

Publication date 20 September 1998

Published in SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://resolver.caltech.edu/CaltechAUTHORS:COHsiamjam98

zbMATH Keywords

boundary layercontrolled drug releasemoving boundary problemsnonlinear diffusion

Mathematics Subject Classification ID

Singular perturbations in context of PDEs (35B25) Asymptotic expansions of solutions to PDEs (35C20) Nonlinear initial, boundary and initial-boundary value problems for linear parabolic equations (35K60) Free boundary problems for PDEs (35R35) Stefan problems, phase changes, etc. (80A22)

Review text

This paper deals with the solution of Higushi's model for controlled release of drugs when the solubility of the drug in the polymer matrix is a prescribed function of time. The model is described as a one-phase moving boundary problem which cannot be solved exactly. Two limits of the problem are considered. The first one considers a solubility much smaller than the initial loading of the drug. This leads to a pseudo-steady-state approximation of the diffusion equation. The second limit considers a solubility close to the initial loading of the drug and requires a boundary layer analysis. Analytical expressions for the release rate are obtained showing the effect of the time-dependent solubility.

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Cited in

(28)

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• Quadratic models to fit experimental data of paclitaxel release kinetics from biodegradable polymers
• Asymptotic and numerical results for a model of solvent-dependent drug diffusion through polymeric spheres
• A moving boundary diffusion model in drug therapeutics
• Modelling chemistry and biology after implantation of a drug-eluting stent. Part I: drug transport
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• scientific article; zbMATH DE number 1180835 (Why is no real title available?)
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• Numerical Simulation of Two Phase Mathematical Model for Transportation of Mass and Drug from Drug Eluting Stents
• Drug diffusion from polymeric delivery devices: a problem with two moving boundaries
• scientific article; zbMATH DE number 2163429 (Why is no real title available?)
• Controlled release drug delivery via polymeric microspheres: a neat application of the spherical diffusion equation
• Quadratic ODE and PDE models of drug release kinetics from biodegradable polymers
• Asymptotic analysis of drug dissolution in two layers having widely differing diffusivities
• Modeling the release of a reagent from an inwardly tapered disk with a central hole
• Flux tracking in drug delivery
• Mathematical models for drug delivery to chronic patients

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