Controlled Drug Release Asymptotics (Q4210035)
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scientific article; zbMATH DE number 1200670
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | No label defined |
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| English | Controlled Drug Release Asymptotics |
scientific article; zbMATH DE number 1200670 |
Statements
Controlled Drug Release Asymptotics (English)
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20 September 1998
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moving boundary problems
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boundary layer
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controlled drug release
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nonlinear diffusion
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0.8515613675117493
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0.8251281976699829
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This paper deals with the solution of Higushi's model for controlled release of drugs when the solubility of the drug in the polymer matrix is a prescribed function of time. The model is described as a one-phase moving boundary problem which cannot be solved exactly. Two limits of the problem are considered. The first one considers a solubility much smaller than the initial loading of the drug. This leads to a pseudo-steady-state approximation of the diffusion equation. The second limit considers a solubility close to the initial loading of the drug and requires a boundary layer analysis. Analytical expressions for the release rate are obtained showing the effect of the time-dependent solubility.
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