Defining functional distance using manifold embeddings of gene ontology annotations

DOI10.1073/PNAS.0702965104MaRDI QIDQ5385921zbMATH OpenOpenAlexWikidataFDO

Authors Gilad Lerman, Boris E. Shakhnovich

Publication date 7 May 2008

Published in Proceedings of the National Academy of Sciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1073/pnas.0702965104

zbMATH Keywords

diffusion geometrydomain evolutionfunctional annotationhomology modelingkernel methods

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Genetics and epigenetics (92D10)

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Cites work

• A theoretical and computational framework for isometry invariant recognition of point cloud data
• Laplacian Eigenmaps for Dimensionality Reduction and Data Representation

Cited in

(3)

• Correlating information contents of gene ontology terms to infer semantic similarity of gene products
• A hierarchical semiparametric model for incorporating intergene information for analysis of genomic data
• A Bayesian extension of the hypergeometric test for functional enrichment analysis

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