False Discovery Rate Estimation for Frequentist Pharmacovigilance Signal Detection Methods

DOI10.1111/J.1541-0420.2009.01262.XMaRDI QIDQ3564588zbMATH OpenOpenAlexWikidataFDO

Authors

Publication date 26 May 2010

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/j.1541-0420.2009.01262.x

zbMATH Keywords

false discovery rateFisher's exact testlocation-based estimatormid-P-valuesmixture modelmultiple comparisonsone-sided P-valuespharmacovigilancereporting odds ratio

Mathematics Subject Classification ID

Testing in survival analysis and censored data (62N03) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

Recommendations

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• Estimating the False Discovery Rate Using Nonparametric Deconvolution

Cites work

• A Direct Approach to False Discovery Rates
• A moment-based method for estimating the proportion of true null hypotheses and its application to microarray gene expression data
• Adaptive linear step-up procedures that control the false discovery rate
• Control of the mean number of false discoveries, Bonferroni and stability of multiple testing
• Correlation and Large-Scale Simultaneous Significance Testing
• scientific article; zbMATH DE number 1817585 (Why is no real title available?)
• scientific article; zbMATH DE number 720689 (Why is no real title available?)
• Statistical significance for genomewide studies

Cited in

(6)

• Likelihood-ratio-test methods for drug safety signal detection from multiple clinical datasets
• Bayesian model selection in logistic regression for the detection of adverse drug reactions
• A likelihood ratio test based method for signal detection with application to FDA's drug safety data
• Accounting for multiplicity in the evaluation of ``signals obtained by data mining from spontaneous report adverse event databases
• An evaluation of statistical approaches to postmarketing surveillance
• A nonparametric Bayesian local-global model for enhanced adverse event signal detection in spontaneous reporting system data

Describes a project that uses

Uses Software

• R

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