Fixation probability for competing selective sweeps

DOI10.1214/EJP.V17-1954MaRDI QIDQ428648zbMATHOpenAlexWikidataFDO

Authors Charles Cuthbertson, Alison Etheridge, Feng Yu

Publication date 22 June 2012

Published in Electronic Journal of Probability (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0812.0104

zbMATH Keywords

fixation probabilitydouble mutant

Mathematics Subject Classification ID

Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Abstract: We consider a biological population in which a beneficial mutation is undergoing a selective sweep when a second beneficial mutation arises at a linked locus and we investigate the probability that both mutations will eventually fix in the population. Previous work has dealt with the case where the second mutation to arise confers a smaller benefit than the first. In that case population size plays almost no role. Here we consider the opposite case and observe that, by contrast, the probability of both mutations fixing can be heavily dependent on population size. Indeed the key parameter is $hoN$, the product of the population size and the recombination rate between the two selected loci. If $hoN$ is small, the probability that both mutations fix can be reduced through interference to almost zero while for large $hoN$ the mutations barely influence one another. The main rigorous result is a method for calculating the fixation probability of a double mutant in the large population limit.

Recommendations

• The fixation probability of two competing beneficial mutations
• The fixation probability and time for a doubly beneficial mutant
• Competing selective sweeps
• Fixation of beneficial mutations in the presence of epistatic interactions
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Cited in

(17)

• The fixation probability and time for a doubly beneficial mutant
• The fixation probability of two competing beneficial mutations
• The probability of fixation of a single mutant in an exchangeable selection model
• Haldane's formula in Cannings models: the case of moderately strong selection
• Fixation probability in a two-locus intersexual selection model
• The effect of recombination on the speed of evolution
• Effect of epistasis and linkage on fixation probability in three-locus models: an ancestral recombination-selection graph approach
• Selective sweep and the size of the hitchhiking set
• Fixation of beneficial mutations in the presence of epistatic interactions
• Role of epistasis on the fixation probability of a non-mutator in an adapted asexual population
• Competing selective sweeps
• Fixation probabilities of additive alleles in diploid populations
• An eco-evolutionary approach of adaptation and recombination in a large population of varying size
• Population structure and the rate of evolution
• Asymptotic behavior of the rate of adaptation
• Extinction and fixation times with dominance and inbreeding
• Fixation probability of a nonmutator in a large population of asexual mutators

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