Haldane's formula in Cannings models: the case of moderately strong selection

DOI10.1007/S00285-021-01698-9MaRDI QIDQ2059535zbMATH OpenOpenAlexWikidataFDO

Authors Florin Boenkost, Adrián González Casanova, Cornelia Pokalyuk, Anton Wakolbinger

Publication date 14 December 2021

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2008.02225

zbMATH Keywords

branching process approximationCannings modeldirectional selectionprobability of fixation

Mathematics Subject Classification ID

Markov chains (discrete-time Markov processes on discrete state spaces) (60J10) Branching processes (Galton-Watson, birth-and-death, etc.) (60J80) Problems related to evolution (92D15) Population dynamics (general) (92D25)

Abstract: For a class of Cannings models we prove Haldane's formula, $pi(s_N)simfrac2s_{N}h{o}^2$, for the fixation probability of a single beneficial mutant in the limit of large population size $N$ and in the regime of moderately strong selection, i.e. for $s_{N}sim{N}^{-b}$ and $0<b<1/2$. Here, $s_N$ is the selective advantage of an individual carrying the beneficial type, and $h{o}^2$ is the (asymptotic) offspring variance. Our assumptions on the reproduction mechanism allow for a coupling of the beneficial allele's frequency process with slightly supercritical Galton-Watson processes in the early phase of fixation.

Recommendations

• Haldane's formula in Cannings models: the case of moderately weak selection
• The probability of fixation of a single mutant in an exchangeable selection model
• Probability of fixation under weak selection: a branching process unifying approach
• The fixation probability and time for a doubly beneficial mutant
• Fixation probability for competing selective sweeps

Cites work

• An individual-based model for the Lenski experiment, and the deceleration of the relative fitness
• Asymptotic rates of growth of the extinction probability of a mutant gene
• Branching Processes
• Duality and fixation in \(\Xi\)-Wright-Fisher processes with frequency-dependent selection
• Haldane's formula in Cannings models: the case of moderately weak selection
• scientific article; zbMATH DE number 410740 (Why is no real title available?)
• scientific article; zbMATH DE number 3410334 (Why is no real title available?)
• Large deviations of heavy-tailed sums with applications in insurance
• Mathematical population genetics. I: Theoretical introduction.
• Modelling and simulating Lenski's long-term evolution experiment
• On the survival probability of a slightly advantageous mutant gene with a general distribution of progeny size. A branching process model
• Probability Inequalities for Sums of Bounded Random Variables
• Probability on trees and networks
• Rates of decay for the survival probability of a mutant gene
• Stochastic ordering of classical discrete distributions
• The latent roots of certain Markov chains arising in genetics: A new approach, I. Haploid models
• The probability of fixation of a single mutant in an exchangeable selection model

Cited in

(11)

• Haldane's formula in Cannings models: the case of moderately weak selection
• Asymptotic genealogies for a class of generalized Wright-Fisher models
• Extinction threshold and large population limit of a plant metapopulation model with recurrent extinction events and a seed bank component
• Lines of descent in a Moran model with frequency-dependent selection and mutation
• On the fixation probability of an advantageous allele in a population with skewed offspring distribution
• Bounds for survival probabilities in supercritical Galton-Watson processes and applications to population genetics
• From clonal interference to Poissonian interacting trajectories
• The mutation process on the ancestral line under selection
• Polygenic dynamics underlying the response of quantitative traits to directional selection
• Bridging Wright-Fisher and Moran models
• Resident fitness computation in linear time and other algorithmic aspects of interacting trajectories

This page was built for publication: Haldane's formula in Cannings models: the case of moderately strong selection

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2059535)