Haldane's formula in Cannings models: the case of moderately weak selection

DOI10.1214/20-EJP572MaRDI QIDQ2042825zbMATH OpenOpenAlexFDO

Authors Florin Boenkost, Adrián González Casanova, Cornelia Pokalyuk, Anton Wakolbinger

Publication date 21 July 2021

Published in Electronic Journal of Probability (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1907.10049

zbMATH Keywords

ancestral selection graphCannings modeldirectional selectionprobability of fixationsampling duality

Mathematics Subject Classification ID

Central limit and other weak theorems (60F05) Markov chains (discrete-time Markov processes on discrete state spaces) (60J10) Population dynamics (general) (92D25) Branching processes (Galton-Watson, birth-and-death, etc.) (60J80)

Abstract: We introduce a Cannings model with directional selection via a paintbox construction and establish a strong duality with the line counting process of a new emph{Cannings ancestral selection graph} in discrete time. This duality also yields a formula for the fixation probability of the beneficial type. Haldane's formula states that for a single selectively advantageous individual in a population of haploid individuals of size $N$ the prob-ability of fixation is asymptotically (as $Noinfty$) equal to the selective advantage of haploids $s_N$ divided by half of the offspring variance. For a class of offspring distributions within Kingman attraction we prove this asymptotics for sequences $s_N$ obeying $N^{-1}ll{s}_{N}ll{N}^{-1/2}$, which is a regime of "moderately weak selection". It turns out that for $s_{N}ll{N}^{-2/3}$ the Cannings ancestral selection graph is so close to the ancestral selection graph of a Moran model that a suitable coupling argument allows to play the problem back asymptotically to the fixation probability in the Moran model, which can be computed explicitly.

Recommendations

• Haldane's formula in Cannings models: the case of moderately strong selection
• The probability of fixation of a single mutant in an exchangeable selection model
• Probability of fixation under weak selection: a branching process unifying approach
• The Moran model with selection: fixation probabilities, ancestral lines, and an alternative particle representation
• The ancestral selection graph under strong directional selection

Cites work

• scientific article; zbMATH DE number 3951715 (Why is no real title available?)
• scientific article; zbMATH DE number 3729228 (Why is no real title available?)
• An individual-based model for the Lenski experiment, and the deceleration of the relative fitness
• Ancestral processes with selection
• Common ancestor type distribution: a Moran model and its deterministic limit
• Duality and fixation in \(\Xi\)-Wright-Fisher processes with frequency-dependent selection
• Mathematical population genetics. I: Theoretical introduction.
• Modelling and simulating Lenski's long-term evolution experiment
• Negative association of random variables, with applications
• Optimization results for a generalized coupon collector problem
• Probability Models for DNA Sequence Evolution
• Solutions of ordinary differential equations as limits of pure jump markov processes
• Some Problems of Stochastic Processes in Genetics
• Tail bounds for sums of geometric and exponential variables
• The ancestral selection graph under strong directional selection
• The latent roots of certain Markov chains arising in genetics: A new approach, I. Haploid models
• Total variation distances and rates of convergence for ancestral coalescent processes in exchangeable population models

Cited in

(8)

• Extinction scenarios in evolutionary processes: a multinomial Wright-Fisher approach
• Lines of descent in a Moran model with frequency-dependent selection and mutation
• \(\Lambda\)-coalescents arising in a population with dormancy
• Extinction threshold and large population limit of a plant metapopulation model with recurrent extinction events and a seed bank component
• Haldane's formula in Cannings models: the case of moderately strong selection
• On the fixation probability of an advantageous allele in a population with skewed offspring distribution
• Probability of fixation under weak selection: a branching process unifying approach
• Asymptotic genealogies for a class of generalized Wright-Fisher models

This page was built for publication: Haldane's formula in Cannings models: the case of moderately weak selection

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2042825)