From Biophysical to Integrate-and-Fire Modeling
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Abstract: This paper proposes a methodology to extract a low-dimensional integrate-and-fire model from an arbitrarily detailed single-compartment biophysical model. The method aims at relating the modulation of maximal conductance parameters in the biophysical model to the modulation of parameters in the proposed integrate-and-fire model. The approach is illustrated on two well-documented examples of cellular neuromodulation: the transition between Type I and Type II excitability and the transition between spiking and bursting.
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- A Generalized Linear Integrate-and-Fire Neural Model Produces Diverse Spiking Behaviors
- A Subspace, Interior, and Conjugate Gradient Method for Large-Scale Bound-Constrained Minimization Problems
- An organizing center in a planar model of neuronal excitability
- Approximate linear realizations of given dimension via Ho's algorithm
- Efficient fitting of conductance-based model neurons from somatic current clamp
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- Linear approximations of nonlinear FIR systems for separable input processes
- Predicting spike timing of neocortical pyramidal neurons by simple threshold models
- Reduction of conductance-based neuron models
- Robust modulation of integrate-and-fire models
Cited in
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