Futility analyses for the MCP-mod methodology based on longitudinal models

DOI10.1002/SIM.70274MaRDI QIDQ6904869zbMATH OpenFDO

Authors Björn Bornkamp, Dong Xi, Weihua Cao, Jie Zhou

Publication date 6 November 2025

Published in Statistics in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/SIM.70274

zbMATH Keywords

conditional powerfutility analysisphase 2 studypredictive powerunblinded sample size re-estimation

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• Combining Multiple Comparisons and Modeling Techniques in Dose‐Response Studies
• Computation of multivariate normal and t probabilities
• Group sequential designs for one-sided and two-sided hypothesis testing with provision for early stopping in favor of the null hypothesis
• Group Sequential Tests for Delayed Responses (with discussion)
• scientific article; zbMATH DE number 1348603 (Why is no real title available?)
• scientific article; zbMATH DE number 1865509 (Why is no real title available?)
• Model-based dose finding under model uncertainty using general parametric models
• Optimal designs for the emax, log-linear and exponential models
• Statistical monitoring of clinical trials. A unified approach.
• Stochastically curtailed tests in long–term clinical trials
• Using simulation studies to evaluate statistical methods

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