Global threshold dynamics of an HIV/AIDS model with multi-class-age structure

DOI10.3934/DCDSB.2024068MaRDI QIDQ6614262zbMATH OpenFDO

Authors Qian Jiang, Zhijun Liu

Publication date 7 October 2024

Published in Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL https://doi.org/10.3934/DCDSB.2024068

zbMATH Keywords

age structuresglobal stabilityHIV/AIDS epidemic modelmulti-stage infectionuniformly persistence

Mathematics Subject Classification ID

Stability of solutions to ordinary differential equations (34D20) Global stability of solutions to ordinary differential equations (34D23) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Epidemiology (92D30)

Review text

The paper studies global threshold dynamics of an HIV/AIDS model with multi-class-age structure. It formulates an age-structured model in the form of partial differential equations to depict the dependence of HIV progress on susceptibility age, infection age, and treatment age. Susceptibility age captures the likelihood of an individual being infected through sexual behavior and lifestyle at different ages. The paper assumes chronological age homogeneity among infected individuals, treated individuals, and AIDS patients. It establishes the global stability of the equilibrium and examines the existence of disease-free equilibrium, endemic equilibrium, and the basic reproduction number associated with different properties. Local stability, uniform persistence, and global stability are analyzed. Some numerical examples are provided to illustrate the theoretical results.

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