PrEP intervention in the mitigation of HIV/AIDS epidemics in China via a data-validated age-structured model

DOI10.1007/S11538-023-01145-4MaRDI QIDQ6044233zbMATH OpenFDO

Authors Peng Wu, Shohel Ahmed, Xiunan Wang, Hao Wang

Publication date 17 May 2023

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/S11538-023-01145-4

zbMATH Keywords

age structureantiretroviral therapyantiretroviral-based pre-exposure prophylaxis (PrEP)HIV/AIDS epidemicsMarkov chain Monte Carlo (MCMC)

Mathematics Subject Classification ID

Stability in context of PDEs (35B35) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Mathematical geography and demography (91D20) Epidemiology (92D30)

Review text

This paper studies PrEP intervention in the mitigation of HIV/AIDS epidemics in China via a data-validated age-structured model. The paper formulates the age-structured HIV/AIDS model with PrEP intervention for the transmission dynamics of HIV/AIDS. The existence of the positive solution for a non-dimensional form of the model is proved. The basic reproduction number is derived and the stability of the disease-free state is proved. The existence and stability of the endemic steady state of the system are obtained. Moreover, the paper establishes the demographic model corresponding to the age-structured model. Some numerical simulations have also been performed to validate the theoretical results.

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Cited in

(15)

• Modeling and control for HIV/AIDS transmission in China based on data from 2004 to 2016
• A model of HIV/AIDS population dynamics including ARV treatment and pre-exposure prophylaxis
• The impact of pre-exposure prophylaxis (PrEP) and screening on the dynamics of HIV
• Pre-exposure prophylaxis HIV/AIDS mathematical model with non classical isolation
• Mathematical insights in evaluating state dependent effectiveness of HIV prevention interventions
• Optimal strategies for mitigating the HIV/AIDS epidemic in the Philippines
• Pre-exposure prophylaxis and antiretroviral treatment interventions with drug resistance
• Impact of population recruitment on the HIV epidemics and the effectiveness of HIV prevention interventions
• Stability analysis of a new differential-difference model applied to the pre-exposure prophylaxis (PrEP) effect on the spread of HIV
• Global threshold dynamics of an HIV/AIDS model with multi-class-age structure
• Dynamic analysis of a degenerated temporal-spatial acquired immunodeficiency syndrome model with voluntary counseling and testing awareness and antiretroviral therapy treatment
• Spatiotemporal dynamics of syphilis in Xinjiang via a demographic-geographic data-validated reaction diffusion model
• Temporal and spatial modeling of the spread of dengue fever in Brazil
• An age-structured syphilis model. II: Optimal control and numerical simulation
• Numerical dynamics and optimal control for multi-strain age-structured epidemic model

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