PrEP intervention in the mitigation of HIV/AIDS epidemics in China via a data-validated age-structured model (Q6044233)

This paper studies PrEP intervention in the mitigation of HIV/AIDS epidemics in China via a data-validated age-structured model. The paper formulates the age-structured HIV/AIDS model with PrEP intervention for the transmission dynamics of HIV/AIDS. The existence of the positive solution for a non-dimensional form of the model is proved. The basic reproduction number is derived and the stability of the disease-free state is proved. The existence and stability of the endemic steady state of the system are obtained. Moreover, the paper establishes the demographic model corresponding to the age-structured model. Some numerical simulations have also been performed to validate the theoretical results.