Heterogeneous viral environment in a HIV spatial model

DOI10.3934/DCDSB.2011.15.545MaRDI QIDQ541563zbMATH OpenOpenAlexFDO

Authors C.-M. Brauner, D. Jolly, Luca Lorenzi, Rodolphe Thiébaut

Publication date 7 June 2011

Published in Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0905.2023

zbMATH Keywords

analytic semigrouppartly dissipative PDE-ODE systempositively invariant region

Mathematics Subject Classification ID

Homogenization in context of PDEs; PDEs in media with periodic structure (35B27) Stability in context of PDEs (35B35) Asymptotic behavior of solutions to PDEs (35B40) Nonlinear parabolic equations (35K55) One-parameter semigroups and linear evolution equations (47D06) Medical applications (general) (92C50)

Abstract: We consider the basic model of virus dynamics in the modeling of Human Immunodeficiency Virus (HIV), in a 2D heterogenous environment. It consists of two ODEs for the non-infected and infected $C{D}_4^{+}$ $T$ lymphocytes, $T$ and $I$, and a parabolic PDE for the virus $V$. We define a new parameter $lambd{a}_0$ as an eigenvalue of some Sturm-Liouville problem, which takes the heterogenous reproductive ratio into account. For $lambd{a}_0<0$ the trivial non-infected solution is the only equilibrium. When $lambd{a}_0>0$, the former becomes unstable whereas there is only one positive infected equilibrium. Considering the model as a dynamical system, we prove the existence of a universal attractor. Finally, in the case of an alternating structure of viral sources, we define a homogenized limiting environment. The latter justifies the classical approach via ODE systems.

Review text

The authors study a partly dissipative PDE-ODE system modeling the dynamics of o particular virus (HIV). Considering the model as a dynamical system, the authors prove the existence of a positively invariant region. For the case of an ``alternating structure of viral sources, an homogeneous limiting environment is defined, matching the classical ode-systems approach to HIV dynamics.

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• Two-dimensional stability analysis in a HIV model with quadratic logistic growth term
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• Global dynamics of a delayed diffusive virus infection model with cell-mediated immunity and cell-to-cell transmission
• Homogenization of a reaction diffusion equation can explain influenza a virus load data
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• Modelling of HIV viral load and 2-LTR dynamics during high active antiretroviral therapy in a heterogeneous environment
• Dynamics of a diffusive virus model with general incidence function, cell-to-cell transmission and time delay
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• Spatial and temporal dynamics of a viral infection model with two nonlocal effects
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• Global dynamics of a PDE in-host viral model
• Mathematical analysis of an in-host model of viral dynamics with spatial heterogeneity
• Global behaviours of an in-host viral model with general incidence terms
• Nonstandard finite difference scheme for a diffusive within-host virus dynamics model with both virus-to-cell and cell-to-cell transmissions
• Spatiotemporal dynamics of a class of models describing infectious diseases
• Dynamics of a diffusive delayed viral infection model in a heterogeneous environment
• Propagation dynamics for a spatial discrete virus model with HIV viral load and 2-LTR dynamics
• Threshold stability analysis of an unconditionally positivity-preserving numerical method for a nonlinear age-structured diffusive HIV model with spatial coefficients
• Threshold propagation in a May-Nowak type degenerate reaction-diffusion viral model on periodically evolving domain
• Dynamics of a PDE viral infection model incorporating cell-to-cell transmission
• Global dynamics of a delay reaction-diffusion model for viral infection with specific functional response

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