The alignment of protein structures in three dimensions (Q1111963)
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English | The alignment of protein structures in three dimensions |
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The alignment of protein structures in three dimensions (English)
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1989
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This article extends the use of dynamic programming algorithms in molecular sequence comparison to the alignment of the \(\alpha\)-carbon \((C_{\alpha})\)-coordinates of two protein structures in three dimensions. The algorithm is described in detail and is applied to the comparison of \(\alpha\)-lactalbumin with both hen egg white lysozyme and T4 lysozyme. In the first case, the structures are similar, while the second comparison is between two distantly related molecules. References are made to the usual sequence alignments. A variety of complementary methods are introduced to display the results.
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alpha-carbon
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molecular biology
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molecular sequence comparison
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protein structures
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three dimensions
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lactalbumin
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lysozyme
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sequence alignments
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