Robust genetic circuit design: a mixed \(\mathcal{H}_{\infty}\) and IQC analysis (Q1798441)

Summary: This paper considers the problem of designing a genetic circuit which is robust to noise effect. To achieve this goal, a mixed \(\mathcal{H}_\infty\) and integral quadratic constraints (IQC) approach is proposed. In order to minimize the effects of external noise on the genetic regulatory network in terms of \(\mathcal{H}_\infty\) norm, a design procedure of Hill coefficients in the promoters is presented. The IQC approach is introduced to analyze and guarantee the stability of the designed circuit.