Robust genetic circuit design: a mixed H_ and IQC analysis
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Publication:1798441
Summary: This paper considers the problem of designing a genetic circuit which is robust to noise effect. To achieve this goal, a mixed \(\mathcal{H}_\infty\) and integral quadratic constraints (IQC) approach is proposed. In order to minimize the effects of external noise on the genetic regulatory network in terms of \(\mathcal{H}_\infty\) norm, a design procedure of Hill coefficients in the promoters is presented. The IQC approach is introduced to analyze and guarantee the stability of the designed circuit.
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Cites work
- Control of linear systems with saturating actuators
- Robust dynamical network structure reconstruction
- Stability of Genetic Networks With SUM Regulatory Logic: Lur'e System and LMI Approach
- State-space solutions to standard H/sub 2/ and H/sub infinity / control problems
- System analysis via integral quadratic constraints
Cited in
(5)- Design and analysis of a robust genetic Muller C-element
- Robust filtering circuit design for stochastic gene networks under intrinsic and extrinsic molecular noises
- Reliable biological circuit design including uncertain kinetic parameters
- Robust model matching design methodology for a stochastic synthetic gene network
- Multiobjective \(H_2/H_\infty\) synthetic gene network design based on promoter libraries
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