Nonlinear dynamics and noise actuated by the cycle of gene inactivation in stochastic transcription (Q2213859)

The authors describe the stochastic process of on/off gene switching by integrating the inactivation cycle with mRNA birth and death processes. Following a comprehensive overview of the state-of-art of the mathematical modeling, they focus on several aspects, such as the regulation of non-monotonic transcription dynamics through gene inactivation recycling (Section 3) and the transcription noise at steady state (Section 4). Section 5 contains detailed proofs of the main results.