surrosurv (Q30016)
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Evaluation of Failure Time Surrogate Endpoints in Individual Patient Data Meta-Analyses
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | No label defined |
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| English | surrosurv |
Evaluation of Failure Time Surrogate Endpoints in Individual Patient Data Meta-Analyses |
Statements
10 October 2025
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Provides functions for the evaluation of surrogate endpoints when both the surrogate and the true endpoint are failure time variables. The approaches implemented are: (1) the two-step approach (Burzykowski et al, 2001) <doi:10.1111/1467-9876.00244> with a copula model (Clayton, Plackett, Hougaard) at the first step and either a linear regression of log-hazard ratios at the second step (either adjusted or not for measurement error); (2) mixed proportional hazard models estimated via mixed Poisson GLM (Rotolo et al, 2017 <doi:10.1177/0962280217718582>).
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Identifiers
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