Time-delayed models of gene regulatory networks (Q307714)
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scientific article; zbMATH DE number 6623232
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| English | Time-delayed models of gene regulatory networks |
scientific article; zbMATH DE number 6623232 |
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Time-delayed models of gene regulatory networks (English)
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5 September 2016
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Summary: We discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternative modelling approaches, we use a paradigmatic two-gene network to focus on the role played by time delays in the dynamics of gene regulatory networks. We contrast the dynamics of the reduced model arising in the limit of fast mRNA dynamics with that of the full model. The review concludes with the discussion of some open problems.
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mRNA dynamics
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time-delayed models
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quasi-steady state assumption
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Hill coefficients
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0.8121835589408875
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0.7897059917449951
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0.7879757285118103
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0.7799262404441833
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