joineRML (Q31246)
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Joint Modelling of Multivariate Longitudinal Data and Time-to-Event Outcomes
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| default for all languages | No label defined |
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| English | joineRML |
Joint Modelling of Multivariate Longitudinal Data and Time-to-Event Outcomes |
Statements
14 June 2026
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Fits the joint model proposed by Henderson and colleagues (2000) <doi:10.1093/biostatistics/1.4.465>, but extended to the case of multiple continuous longitudinal measures. The time-to-event data is modelled using a Cox proportional hazards regression model with time-varying covariates. The multiple longitudinal outcomes are modelled using a multivariate version of the Laird and Ware linear mixed model. The association is captured by a multivariate latent Gaussian process. The model is estimated using a Monte Carlo Expectation Maximization algorithm. This project was funded by the Medical Research Council (Grant number MR/M013227/1).
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Identifiers
23 January 2023
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